env \ PATH=”$(brew –prefix tcl-tk)/bin:$PATH” \ LDFLAGS=”-L$(brew –prefix tcl-tk)/lib” \ CPPFLAGS=”-I$(brew –prefix tcl-tk)/include” \ PKG_CONFIG_PATH=”$(brew –prefix tcl-tk)/lib/pkgconfig” \ CFLAGS=”-I$(brew –prefix tcl-tk)/include” \ PYTHON_CONFIGURE_OPTS=”–with-tcltk-includes=’-I$(brew –prefix tcl-tk)/include’ –with-tcltk-libs=’-L$(brew –prefix tcl-tk)/lib -ltcl8.6 -ltk8.6′” \ pyenv install

Source : Install tkinter on Mac. (pyenv). Install tcl-tk | by Taeha Hong | Medium